In June 2021, the U.S. Food and Drug Administration approved the Wegovy semaglutide injection “for chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, Type 2 diabetes, or high cholesterol), for use in addition to a reduced calorie diet and increased physical activity.”

Semaglutide, when used responsibly under professional medical supervision, “acts on centers in the brain and suppresses appetite”, according to research reported by the University of Alabama–Birmingham. In addition, it can reduce weight through cellular detoxification, reduced cravings, stabilized blood sugar and the slowing of the emptying of the stomach, which helps users feel full longer. 

“The makers of Wegovy emphasize that eating healthier is what creates much of the weight loss, but many of our patients agree that drastic lifestyle changes aren’t necessary,” explains Jennifer Hruz, a board-certified family nurse practitioner, advanced practice nurse prescriber and founder of VIVA Wellness. “Instead, the protocol tends to inspire a natural rewiring of their dietary habits.” Hruz continues, “While semaglutide works in a few ways, one way is that it targets hunger centers in the brain to stabilize constant hunger, cravings or food chatter thoughts.”

There are a few key protocols—such as side effect management and responsible dosing— that are needed for safe and successful use of semaglutide, suggesting that having a healthcare provider as part of the process results in the best outcomes. The body experiences much as it adjusts to the medication, and having provider support during this period is critical to ensuring success and quality of life.

With medical supervision, semaglutide can be combined with injections, oral supplements and holistic treatments, such as colonics and lymphatic drainage, to support metabolic health and detoxification pathways. The addition of holistic modalities can help release toxins with any fat loss.